New Bio/Circadian Rhythm Research
Circadian clock system plays vital roles in the regulation of physiological processes, including cell cycle progression, cytokine release, hormone secretion, sleep and wakefulness, immune regulation, etc. Multiple systemic diseases are proven to be closely associated with circadian rhythm disorders, so chronobiology research is becoming a focal point in biological and medical fields at present. With the development of chronobiology in these years, external cues that can be used as synchronizers to reset the circadian oscillators of animals or cells have been gradually discovered. From time-serial collection to real-time monitoring through luciferase reporter genes and fluorescent proteins, the methods to observe biological rhythms are rapidly advancing and becoming more diverse. In addition, researchers have also established a number of circadian clock-related databases to facilitate access to previous research results. Through the combination of various in vivo and in vitro experiments, the mechanisms underlying circadian oscillations are constantly being elucidated, and the complicated connections between circadian rhythm disorders and various diseases are also being identified. Illuminating the crosstalk between circadian rhythm and human diseases can help us better clarify the pathogenesis of circadian-related diseases, which provides new strategies and ideas for disease prevention and treatment.